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Eur J Pharmacol 606:205209 Vitvitsky V, Thomas M, Ghorpade A, Gendleman HE, Banerjee R (2006) A functional transulfuration pathway in the brain links to glutathione homeostasis

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Olopatadine Hydrochloride: Olopatadine demonstrated no tumorigenic potential in mice at oral doses up to 500 mg/kg/day (approximately 510 times the MRHDID on a mg/m2 basis) for 78 weeks or in rats at oral doses up to 200 mg/kg/day (approximately 410 times the MRHDID on a mg/m2 basis) for 104 weeks